EXOSOMAL MIR-301A-3P FROM ESOPHAGEAL SQUAMOUS CELL CARCINOMA CELLS PROMOTES ANGIOGENESIS BY INDUCING M2 POLARIZATION OF MACROPHAGES VIA THE PTEN/PI3K/AKT SIGNALING PATHWAY

Abstract Background Growing evidence has indicated that tumor-associated macrophages (TAMs) promote tumor angiogenesis.However, the mechanisms underlying the pro-angiogenic switch of TAMs remains unclear.Here, we examined how exosomal miR-301a-3p secreted by esophageal squamous cell carcinoma (ESCC) cells triggers the pro-angiogenic Rim Tape switch

Relevance.Nowadays Russia is creating an intelligence power system with active-adaptive grid (Smart Grid)in.The complexity of the elements design of the Smart Grid architecture calls for the creation of PLM-system for their implementation.This PLM-system is supposed to predict the improvement in the R&D of electrical and environmental performance o

Epithelial ovarian cancer is the deadliest gynecological malignancy.The lack of effective treatments highlights the need for novel therapeutic interventions.The aim of this study was to investigate whether sustained adeno-associated virus (AAV) vector-mediated expression of vascular normalizing agents 3TSR and Fc3TSR and the antiangiogenic monoclon